期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 10, 期 87, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2013.0459
关键词
in vivo biomechanics; optic nerve head deformations; intraocular pressure; optical coherence tomography; digital volume correlation; glaucoma
资金
- Ministry of Education, Singapore
- Imperial College Junior Research Fellowship, London, UK
- Royal Society Wolfson Research Merit Award
- National Institute for Health Research (NIHR) Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust
- National Institute for Health Research (NIHR) Biomedical Research Centre based at UCL Institute of Ophthalmology
Measurement of optic nerve head (ONH) deformations could be useful in the clinical management of glaucoma. Here, we propose a novel three-dimensional tissue-tracking algorithm designed to be used in vivo. We carry out preliminary verification of the algorithm by testing its accuracy and its robustness. An algorithm based on digital volume correlation was developed to extract ONH tissue displacements from two optical coherence tomography (OCT) volumes of the ONH (undeformed and deformed). The algorithm was tested by applying artificial deformations to a baseline OCT scan while manipulating speckle noise, illumination and contrast enhancement. Tissue deformations determined by our algorithm were compared with the known (imposed) values. Errors in displacement magnitude, orientation and strain decreased with signal averaging and were 0.15 mu m, 0.15 degrees and 0.0019, respectively (for optimized algorithm parameters). Previous computational work suggests that these errors are acceptable to provide in vivo characterization of ONH biomechanics. Our algorithm is robust to OCT speckle noise as well as to changes in illumination conditions, and increasing signal averaging can produce better results. This algorithm has potential be used to quantify ONH three-dimensional strains in vivo, of benefit in the diagnosis and identification of risk factors in glaucoma.
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