期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 8, 期 62, 页码 1281-1297出版社
ROYAL SOC
DOI: 10.1098/rsif.2010.0729
关键词
nucleic acids; synthetic biology; strand displacement circuits; molecular programming
资金
- NSF [0728703, 0832824]
- HFSP [RGY0074/2006-C]
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [0728703] Funding Source: National Science Foundation
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [832824] Funding Source: National Science Foundation
The prospects of programming molecular systems to perform complex autonomous tasks have motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to create cascades that implement digital and analogue circuits. To date, circuits involving at most tens of gates have been demonstrated experimentally. Here, we propose a simple DNA gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates.
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