期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 5, 期 18, 页码 15-45出版社
ROYAL SOC
DOI: 10.1098/rsif.2007.1021
关键词
single-molecule; fluorescence; force; FRET; tracking; AFM; optical tweezers
资金
- NIGMS NIH HHS [R01 GM066833, R01GM066833, R01GM073104, R01 GM073104] Funding Source: Medline
Single-molecule methods have matured into powerful and popular tools to probe the complex behaviour of biological molecules, due to their unique abilities to probe molecular structure, dynamics and function, unhindered by the averaging inherent in ensemble experiments. This review presents an overview of the burgeoning field of single-molecule biophysics, discussing key highlights and selected examples from its genesis to our projections for its future. Following brief introductions to a few popular single-molecule fluorescence and manipulation methods, we discuss novel insights gained from single-molecule studies in key biological areas ranging from biological folding to experiments performed in vivo.
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