期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 5, 期 -, 页码 S17-S28出版社
ROYAL SOC
DOI: 10.1098/rsif.2008.0045.focus
关键词
circadian clocks; phase response curves; coupled oscillators; control; stochastic simulations
资金
- ICB [DAAD19-03-D-0004]
- NIH [GM078993, EB007511]
- NSF IGERT [DGE02-21715]
- Army Research Office [W911NF-07-1-0279]
- US DOE
- AFRL/HEP
Systems theoretic tools (i.e. mathematical modelling, control, and feedback design) advance the understanding of robust performance in complex biological networks. We highlight phase entrainment as a key performance measure used to investigate dynamics of a single deterministic circadian oscillator for the purpose of generating insight into the behaviour of a population of (synchronized) oscillators. More specifically, the analysis of phase characteristics may facilitate the identification of appropriate coupling mechanisms for the ensemble of noisy (stochastic) circadian clocks. Phase also serves as a critical control objective to correct mismatch between the biological clock and its environment. Thus, we introduce methods of investigating synchrony and entrainment in both stochastic and deterministic frameworks, and as a property of a single oscillator or population of coupled oscillators.
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