期刊
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
卷 12, 期 4, 页码 617-623出版社
HINDAWI LTD
DOI: 10.1177/1470320311406572
关键词
Angiotensin-converting enzyme; association; high-altitude pulmonary oedema; insertion/deletion polymorphism; meta-analysis
资金
- National High-Tech Research and Development Program of China [2006AA02A406]
- Seed Foundation of Development on Science and Technology
- Capital Medical University Beijing Anzhen Hospital [2010Z10]
- National Science Foundation for Young Scientists of China [81000109]
- Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University
Background and objective: High-altitude pulmonary oedema (HAPE) is a non-cardiogenic hydrostatic oedema involving a genetic component. Considering the low incidence of HAPE, sample sizes in current reports are relatively limited. We aimed to assess the association between the angiotensin-converting enzyme (ACE) I/D polymorphism and HAPE via a meta-analysis of published and unpublished data. Materials and methods: We searched PubMed, CBM, CNKI, and Cochrane Library Database before 20 November 2010. A random-effects model was applied (STATA) and study quality was assessed in duplicate. Results: A total of five studies including 305 cases and 662 controls were meta-analysed. The summary odds ratio (OR) indicated that no significant differences in risk of developing HAPE were found between carriers of ACE D and I alleles (OR = 1.20; 95% confidence interval (CI), 0.98-1.48; p = 0.084). Lack of association persisted for genotypes under the recessive mode. However, genotype association under the dominant mode showed D allele carriers significantly conferred a 1.55-fold increased HAPE risk compared with II genotype carriers (95% CI, 1.15-2.08; p = 0.004). Funnel plot and Egger's test suggested no evidence of publication bias. Conclusions: Our results supported the notion that ACE D allele carriers were at significant increased risk of developing HAPE.
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