期刊
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
卷 18, 期 1, 页码 54-58出版社
WILEY
DOI: 10.1111/jns5.12008
关键词
cornea; neuropathy; peripheral nerve
资金
- Research to Prevent Blindness Foundation
- [NIHR01DK064814]
- [ADA08-CR52]
- [ADA 70110AEC-23]
In order to develop an efficient, reproducible, and well-tolerated protocol for assessing corneal innervation, 11 normal subjects underwent corneal confocal microscopy (CCM) using a Heidelberg Retinal Tomography III microscope. Five standardized locations were sampled in the left eye and one centrally in the right. The protocol was repeated 14weeks later. A blinded technician measured nerve fiber length (NFL) and tortuosity coefficient (TC). The relationship between image location and NFL and TC was assessed using one-way analysis of variance, and reproducibility determined using relative intertrial variability and intraclass correlation coefficients. NFL reproducibility was maximized by averaging four or more images from the left eye, or one central image from both eyes. TC was less reproducible. CCM is a rapid, well-tolerated, and reproducible method for assessing corneal innervation.
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