期刊
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
卷 26, 期 2, 页码 443-455出版社
OPTICAL SOC AMER
DOI: 10.1364/JOSAA.26.000443
关键词
-
类别
资金
- Engineering and Physical Sciences Research Council (UK) (EPSRC)
- Engineering and Physical Sciences Research Council [EP/E050980/1, EP/D069181/1] Funding Source: researchfish
- EPSRC [EP/D069181/1, EP/E050980/1] Funding Source: UKRI
Biomedical photoacoustic tomography (PAT) can provide qualitative images of biomedical soft tissue with high spatial resolution. However, whether it is possible to give accurate quantitative estimates of the spatially varying concentrations of the sources of photoacoustic contrast-endogenous or exogenous chromophores-remains an open question. Even if the chromophores' absorption spectra are known the problem is nonlinear and ill-posed. We describe a framework for obtaining such quantitative estimates. When the optical scattering distribution is known, adjoint and gradient-based optimization techniques can be used to recover the concentration distributions of the individual chromophores that contribute to the overall tissue absorption. When the scattering distribution is unknown, prior knowledge of the wavelength dependence of the scattering is shown to be sufficient to overcome the absorption-scattering nonuniqueness and allow both distributions of chromophore concentrations and scattering to be recovered from rnultiwavelength photoacoustic images. 2009 (C) Optical Society of America
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据