期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 338, 期 1-2, 页码 223-225出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2013.12.043
关键词
Reversible cerebral vasoconstriction syndrome; Thrombotic thrombocytopenic purpura; Transcranial Doppler; Thunderclap headache; Plasmapheresis; Cerebral vasculitis
Background: Reversible cerebrovascular constriction syndrome (RCVS) presents with thunderclap headache and ischemic neurological deficits due to focal vasoconstrictions in major intracranial arteries. Reversibility of focal vasoconstrictions is the hallmark of RCVS. The commonest conditions associated with RCVS are a post-partum state and administration of vasoactive agents. Methods: We describe a series of 3 cases of thrombotic thrombocytopenic purpura (TTP) who presented with thunderclap headache and focal neurological deficits. Results: Vascular imaging revealed focal areas of constrictions in multiple intracranial arteries. All cases were treated with plasmapheresis and serial transcranial Doppler (TCD) and magnetic resonance angiography revealed resolution of cerebral vasoconstriction, accompanied by clinical recovery. Conclusion: RCVS should be considered in patients with TTP who presented with thunderclap headache. TCD is an important tool for monitoring the course of cerebral vasoconstriction in TTP. (C) 2014 Elsevier B.V. All rights reserved.
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