期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 347, 期 1-2, 页码 50-58出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2014.09.018
关键词
Spinocerebellar ataxia; Voxel-based morphometry; Parahippocampal gyrus; SARA
资金
- DGAPA-Programa de Becas Postdoctorales
- DGAPA-PAPIIT from Universidad Nacional Autonoma de Mexico [IN221413]
- CONACYT [102314]
Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients. (C) 2014 Elsevier B.V. All rights reserved.
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