期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 339, 期 1-2, 页码 57-63出版社
ELSEVIER
DOI: 10.1016/j.jns.2014.01.020
关键词
Multiple sclerosis; Health-related quality of life; Longitudinal; Prognostic factors; Population-based; Quality of life
资金
- Stockholm County Council and Karolinska Institutet
- Doctoral School in Health Care Sciences at Karolinska Institutet
- Swedish Research Council [K2009-69X-21163-01-0]
Background: Health-related quality of life (HRQL) in people with multiple sclerosis (PwMS) is negatively affected compared to that of the general population. Cognitive impairment and depressive symptoms have been shown to predict worse HRQL in a short-term perspective. Considering the progressive nature of MS, it is essential to include the long-term (10 years) perspective of HRQL in PwMS. Objectives: The aim of this 10-year follow-up of a population-based sample of PwMS was to explore changes in and the predictive value of personal factors, degree of MS disability, depressive symptoms and cognitive impairment on HRQL Methods: Data on personal and disease-specific factors, mood, and cognitive function was collected. Data on HRQL was collected, seen as a health profile with the Sickness Impact Profile, as a health index with the EuroQol 5D and as a single global question with the EQ Visual Analog Scale. Results: HRQL worsened over 10 years according to the health profile (Sickness Impact Profile Total and its physical dimension) and according to the health index. The effect sizes were small. HRQL assessed with the single global question remained unchanged. Depressive symptoms and cognitive impairment predicted worse HRQL Conclusion: In a 10-year perspective the HRQL with regard to its physical domain or when seen as a total health profile tends to get worse in PwMS. Yet, HRQL with regard to its psychosocial domain and with regard to PwMS' self-rated health, remains stable. There is a potential for health-care professionals to decrease the impact of modifiable factors on HRQL in PwMS by identifying those with depressive symptoms and/or cognitive impairment and initiating evidence-based treatment as well as meeting the need for environmental facilitators aiming at reducing disability. (C) 2014 Elsevier B.V. All rights reserved.
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