期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 322, 期 1-2, 页码 200-205出版社
ELSEVIER
DOI: 10.1016/j.jns.2012.05.032
关键词
High resolution MRA; Lenticulostriate arteries; Subcortical vascular dementia
资金
- Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea [A102065]
- Samsung Medical Center Clinical Research Development Program [CRL-108011, CRS 110-14-1]
- International Research & Development Program of the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology (MEST) of Korea [20110031541]
- Gil Foundation
Recent studies have demonstrated that ultra-high resolution MRA imaging using 7 Tessla (T) MRI can be employed to noninvasively visualize the lenticulostriate arteries (LSA) that supply the basal ganglia and internal capsule. Subcortical vascular dementia (SVaD) is believed to involve these regions from an early stage. We investigated whether LSA abnormalities measured by 7 T MRA correlate with MRI ischemia markers and neuropsychological/motor deficits. A total of 24 subjects (12 with SVaD, 12 normal controls (NC)) were imaged with 3 T and 7 T MRIs. We assessed the severity of white matter hyperintensities (WMH) and the number of lacunes and microbleeds (MB) by visually inspecting images obtained from conventional 3 T MRI. We also analyzed three-dimensional models of the measured LSAs obtained from 7 T MRI. Compared to the NC, the SVaD subjects had fewer branches of LSAs and greater radii of LSAs. The number of branches was correlated with the number of lacunes. The number of branches was correlated with the delayed recall scores on Rey's Complex Figure Test (RCFT). While not quite reaching statistical significance, the immediate recall, recognition scores on the RCFT, recognition scores on the Seoul Verbal Learning Test, and the word and color readings of Stroop trended in the direction of correlation with the number of branches, as well as with the extrapyramidal scores. Our findings suggest that LSA imaging using 7 T MRI might be a potent candidate for the detection of SVaD. (C) 2012 Elsevier B.V. All rights reserved.
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