期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 300, 期 1-2, 页码 164-164出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2010.09.028
关键词
Sjogren's Syndrome; Barbiturate; Side-effects
Even after the introduction of new antiepileptic drugs, phenobarbital continues to be largely used in the treatment of epilepsy. We report the case of a 59-year-old woman with focal seizures with secondary generalization, treated with phenobarbital with normal serum levels. After thirty days she showed Sjogren-like symptoms, which resolved after the replaced of phenobarbital with oxcarbazepine. Although many antiepileptic drugs are known to induce autoimmune disorders, a Sicca Syndrome has never been reported as an adverse effect of phenobarbital. We think this case report leads to take into consideration the possibility of a drug-induced disorder whenever patients treated with barbiturates develop symptoms suggestive of Sjogren's Syndrome. (C) 2010 Elsevier B.V. All rights reserved.
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