期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 291, 期 1-2, 页码 12-16出版社
ELSEVIER
DOI: 10.1016/j.jns.2010.01.013
关键词
Parkinson's disease; Dopamine agonist; Ropinirole; Neurotrophic factor; NGF; BDNF; GDNF
In Parkinson's disease, cell death is selectively induced in mesencephalic nigral dopaminergic neurons. At present, no disease modifying therapy or radical treatment has been found for this disease. Some dopamine agonists may have a neuroprotective action in cultured cells and animal models. In the present study, we examined stimulating effects of a non-ergoline D-2 dopamine agonist, ropinirole, on synthesis/secretion of neurotrophic factors, including NGF, BDNF, and GDNF, in cultured mouse astrocytes. These effects were compared with those of ergoline dopamine agonists, SKF-38393, a D-1 agonist, bromocriptine, D-2 agonist, and apomorphine, D-1/D-2 agonist. Ropinirole elevated GDNF levels to 4-fold, and NGF levels to 6.3-fold, compared with the control group. Of the dopamine agonists examined, ropinirole produced and secreted more GDNF than a 1.8-fold greater amount of apomorphine, a lesser amount of bromocriptine, or a 2.8-fold greater amount of SKF-38393, which served as the control group. (C) 2010 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据