期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 282, 期 1-2, 页码 5-11出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2009.01.012
关键词
Multiple sclerosis; Clinically isolated syndromes; Magnetic resonance imaging; Grey matter
资金
- Multiple Sclerosis Society of Great Britain and Northern Ireland
- National Institute for Health Research Biomedical Research Centers
In Multiple sclerosis (MS) it is emerging that the most visible element of pathology, white matter (WM) lesions, represents only a fraction of the disease burden borne by the brain; non-lesional WM is also damaged, as is the grey matter (GM). Evidence is also accruing that GM damage may be a major determinant of longer-term outcomes in MS, and that such damage occurs from the earliest clinical stages of the disease. In this review, we focus on the early stages of relapse onset MS, considering the nature, extent and evolution of GM pathology, as determined using magnetic resonance imaging. (C) 2009 Elsevier B.V. All rights reserved.
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