期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 276, 期 1-2, 页码 38-40出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2008.08.025
关键词
Multiple sclerosis; Impaired attention; Methylphenidate
Background and purpose: Attention is one of the major cognitive domains adversely affected in multiple sclerosis (MS). The aim of the current study was to determine the effect of a single dose of methylphenidate on cognitive performance of MS patients with significant attention deficit. Methods: In a double-blind placebo-controlled study design, 26 MS patients with impaired attention were randomly assigned to receive a single dose of 10 mg methylphenidate or placebo. Attention was assessed using the paced auditory serial addition test for 3 and 2 s (PASAT3 and PASAT2) at baseline and I h after drug/placebo administration. Results: Methylphenidate significantly improved performance of both PASAT3 and PASAT2 tests by 22.8% and 25.6% respectively (p<0.001), while no significant changes were observed in placebo treated patients. Conclusion: Administration of a single dose of methylphenidate significantly improved attention in MS patients with considerable attention deficit. (C) 2008 Elsevier B.V. All rights reserved.
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