期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 282, 期 1-2, 页码 34-38出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2008.12.013
关键词
T2 hypointensity; Deep gray matter; Iron deposition; EAE; TMEV; Theiler's murine encephalitis virus; Multiple sclerosis; Multiple sclerosis animal model; MS; MRI; Magnetic resonance imaging
资金
- NINDS NIH HHS [R01 NS058698, R01 NS058698-01A2] Funding Source: Medline
Advanced MRI studies demonstrated several diffuse non-lesional features in multiple sclerosis, including changes detectable in gray matter areas. Standard T2 weighted MRI scans of deep gray matter structures, including the thalamus, caudate, putamen, dentate nuclei often demonstrate hypointensity. T2 hypointensity has been shown to correlate with cognitive, neuropsychiatric and motor dysfunction. The exact pathogenesis of this MRI phenomenon remains unknown. In this manuscript, we demonstrate the first known MS animal model of deep gray matter T2 hypointensity. In TMEV infected SJL/J mice, gradual development of thalamic T2 hypointensity was noted over the disease course. Quantitative analysis of the hypointensity demonstrated a strong correlation between the degree of T2 hypointensity and rotarod detectable disability. We propose that this model will allow mechanistic studies investigating the pathogenesis and significance of deep gray matter T2 hypointensity in MS. (C) 2008 Elsevier B.V. All rights reserved.
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