期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 287, 期 1-2, 页码 105-107出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2009.08.040
关键词
Neuromyelitis optica; Myasthenia gravis; Anti-aquaporin-4 antibody; Anti-acetylcholine receptor antibody; Thymectomy
资金
- Japan Biological Informatics Consortium
- The National Institute of Advanced Industrial Science and Technology
We describe 2 patients who developed anti-aquaporin-4 antibody-positive neuromyelitis optica (NMO) following the development of anti-acetylcholine receptor antibody-positive myasthenia gravis (MG). A literature review of 13 similar cases in addition to the present 2 cases of NMO with MG showed predominance among Asian women and frequent development of NMO following thymectomy for MG. Moreover, in one of our patients, serial assays of anti-aquaporin-4 antibody and anti-acetylcholine receptor antibody were performed. Accumulating evidence for the coexistence of NMO and MG suggests that a common immunopathogenesis of NMO and MG may exist, and the association of NMO with MG may be more frequent than hitherto believed. (C) 2009 Elsevier B.V. All rights reserved.
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