期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 282, 期 1-2, 页码 39-46出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2008.12.035
关键词
Multiple sclerosis; Atrophy; Deep gray matter structures; Inverse consistent nonlinear registration; Tensor based morphometry
资金
- National Institutes of Health [EB002095, S10 RR19186]
Tensor based morphometry (TBM) was applied to determine the atrophy of deep gray matter (DGM) structures in 88 relapsing multiple sclerosis (MS) patients. For group analysis of atrophy, an unbiased atlas was constructed from 20 normal brains. The MS brain images were co-registered with the unbiased atlas using a symmetric inverse consistent nonlinear registration. These studies demonstrate significant atrophy of thalamus, caudate nucleus, and putamen even at a modest clinical disability, as assessed by the expanded disability status score (EDSS). A significant correlation between atrophy and EDSS was observed for different DGM structures: (thalamus: r -0.51, p=3.85 x 10(-7); cauclate nucleus: r=-0.43, p=2.35 x 10(-5); putamen: r=-0.36, p=6.12 x 10(-6)). Atrophy of these structures also correlated with 1) T2 hyperintense lesion volumes (thalamus: r=-0.56, P=9.96 x 10(-9); cauclate nucleus: r=-0.31, p=3.10 x 10(-3); putamen: r=-0.50, p=6.06 x 10(-7)), 2) T1 hypointense lesion volumes (thalamus: r=-0.61, p=2.29 x 10(-10): caudate nucleus: r=-0.35, p=9.51 x 10(-4): putamen: r=-0.43, p=3.51 x 10(-5)), and 3) normalized CSF volume (thalamus: r=-0.66. p=3.55 x 10(-12); cauclate nucleus: r=-0.52, p=2.31 x 10(-7), and putamen: r=-0.66, r=2.13 x 10(-12)). More severe atrophy was observed mainly in thalamus at higher EDSS. These studies appear to suggest a link between the white matter damage and DGM atrophy in MS. (C) 2008 Elsevier B.V. All rights reserved.
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