Prenatal cerebral magnetic resonance imaging

Ultrasonography (USG) is the preferred screening method for fetal brain examination. It has some technical limitations and a relatively low sensibility and specificity for many central nervous system (CNS) malformations. Fetal cerebral magnetic resonance imaging (MRI) offers better resolution and sensibility, with scarce limitations. Objectives: To determine the fetal age according to cortical maturation as seen in MRI, correlating these data with those obtained by means of USG measurements; to correlate USG pathological findings with the MRIs and to determine how the sequence of, cortical maturation varies in abnormal brains. Materials and methods: 50 pregnant women were submitted to USG and fetal brain MRI. Fifteen carried out normal pregnancies. In the remaining 35, the USG, the clinical assessment OF both, raised the suspicion of a CNS malformation. Facts studied were: the gestational age calculated by USG, analysis of the cortical gyral development by MRI (cortical age), the presence of CNS abnormalities and the cot-relation between the cortical maturation and the presence of CNS pathologies. Statistical analysis included the Student's t test for paired samples, the Pearson's correlation coefficient (r) and linear regression curves. Results: In the control group, fetal age highly correlated with the cortical age estimated by MRI. In the abnormal group, a wide variety of pathologies could be found, with higher sensibility and specificity than USG when applying MRI techniques. Cortical age did not correlate with the gestational age in this group: moreover, its estimation could not be achieved in severely malformed brains. Discussion: MRI allows a detailed study of the CNS before birth. It proved to be more reliable and specific than USG, with fewer technical limitations. Cortical maturation can be accurately assessed by this method in normal or slightly abnormal fetuses. However, USG is better than MRI for diagnosing skull bony defects. (C) 2008 Elsevier B.V. All rights reserved.