期刊
JOURNAL OF THE NATIONAL SCIENCE FOUNDATION OF SRI LANKA
卷 38, 期 2, 页码 145-149出版社
NATL SCIENCE FOUNDATION SRI LANKA
DOI: 10.4038/jnsfsr.v38i2.2041
关键词
EAC cells; Hepatotoxicity; HHP; histopathology; PDH; PHP
Hepatotoxicity of three Schiff bases viz. PDH [N-(1-phenyl-2-hydroxy-2-phenyl ethylidine)-2',4' dinitrophenyl hydrazine], PHP[N-(1-phenyl-2-hydroxy-2-phenylethylidine) 2' hydroxy phenyl imine] and HHP [N-(2-hydroxy benzylidine)-2' hydroxy phenyl imine] in both mice with and without Ehrlich Ascites Carcinoma (EAC) was studied. The parameters selected were serum level of the enzymes alanine transaminase, aspartic transaminase, alkaline phosphatase, glucose, blood urea and cholesterol. In mice with no carcinoma there was a modest increase in all the above parameters during the treatment period (10 consecutive days at the dose of 2 mg/kg). After treatment the enhanced values gradually decreased to normal levels. In EAC bearing mice, the toxic effects due to EAC cells in all cases were found to be nullified by treatment of the test compounds. No significant abnormalities in histology of the various organs of the mice were detected due to such treatments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据