期刊
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
卷 100, 期 8, 页码 948-951出版社
NATL MED ASSOC
DOI: 10.1016/S0027-9684(15)31410-3
关键词
sickle cell anemia; corticosteroids; adverse events; vaso-occlusion bone
资金
- National Center for Research Resources [K12RR17613, 2MOIRR10284-10]
- National Heart, Lung and Blood Institute, National Institutes of Health (NIH), Bethesda, MD [R25 HL003679-08, 1 R01 HL079912-02]
Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCID who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.
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