期刊
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
卷 111, 期 3, 页码 301-310出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/djy141
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资金
- Prostate Cancer Foundation Young Investigator Award
- Prostate Cancer Challenge Grant
Background Immunotherapy has been less successful in treating prostate cancer than other solid tumors. We sought to better understand the immune landscape in prostate cancer and identify immune-related biomarkers and potential therapeutic targets. Methods We analyzed gene expression data from 7826 prospectively collected prostatectomy samples (2013-2016), and 1567 retrospective samples with long-term clinical outcomes, for a total of 9393 samples, all profiled on the same commercial clinical platform in a CLIA-certified lab. The primary outcome was distant metastasis-free survival (DMFS). Secondary outcomes included biochemical recurrence-free survival (bRFS), prostate cancer-specific survival (PCSS), and overall survival (OS). All statistical tests were two-sided. Results Unsupervised hierarchical clustering of hallmark pathways demonstrated an immune-related tumor cluster. Increased estimated immune content scores based on immune-specific genes from the literature were associated with worse bRFS (hazard ratio [HR]=1.26 [95% confidence interval [CI]=1.12 to 1.42]; P<.001), DMFS (HR=1.34 [95% CI=1.13 to 1.58]; P<.001), PCSS (HR=1.53 [95% CI=1.21 to 1.92]; P<.001), and OS (HR=1.27 [95% CI=1.07 to 1.50]; P=.006). Deconvolution using Cibersort revealed that mast cells, natural killer cells, and dendritic cells conferred improved DMFS, whereas macrophages and T-cells conferred worse DMFS. Interestingly, while PD-L1 was not prognostic, consistent with its low expression in prostate cancer, PD-L2 was expressed at statistically significantly higher levels (P<.001) and was associated with worse bRFS (HR=1.17 [95% CI=1.03 to 1.33]; P=.01), DMFS (HR=1.25 [95% CI=1.05 to 1.49]; P=.01), and PCSS (HR=1.45 [95% CI=1.13 to 1.86]; P=.003). PD-L2 was strongly associated with immune-related pathways on gene set enrichment analysis suggesting that it is playing an important role in immune modulation in clinical prostate cancer samples. Furthermore, PD-L2 was correlated with radiation response pathways, and also predicted response to postoperative radiation therapy (PORT) on multivariable interaction analysis (P=.03). Conclusion In the largest study of its kind to date, these results illustrate the complex relationship between the tumor-immune interaction, prognosis, and response to radiotherapy, and nominate PD-L2 as a potential novel therapeutic target in prostate cancer, potentially in combination with radiotherapy.
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