期刊
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
卷 106, 期 10, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/dju267
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资金
- European Commission [LSHC-CT-2006-018702]
- Cancer Research UK Programme [C588/A4994, C588/A10589]
- Cancer Research UK [C8216/A6129]
- US National Institutes of Health (NIH) [CA83115]
- NIH, National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics
- Wellcome Trust [076113, WT084766/Z/08/Z]
- Stockholm: Swedish Cancer Society, Karolinska Institutet's research funds
- Lund: Swedish Cancer Society
- Lund: Gunnar Nilsson Foundation
- Lund: European Research Council [ERC-2011-294576]
- Genoa: Italian Ministry of Education, University and Research
- Genoa: IMI
- Genoa: Mara Naum foundation
- University of Genoa [D31J13000000005]
- Intergruppo Melanoma Italiano and Mara Naum foundation
- National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Institut National du Cancer [INCa-PL016]
- Ligue Nationale Contre Le Cancer [PRE05/FD, PRE 09/FD]
- Programme Hospitalier de Recherche Clinique [AOM-07-195]
- Ligue Nationale Contre Le Cancer doctoral fellowship
- European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)-Netherlands hub [CO18]
- Fondo de Investigaciones Sanitarias, Spain [09/01393]
- CIBER de Enfermedades Raras of the Instituto de Salud Carlos III, Spain
- Catalan Government, Spain [AGAUR 2009 SGR 1337]
- Comprehensive Cancer Center, Oslo University Hospital [SE0728]
- Norwegian Cancer Society [71512-PR-2006-0356]
- National Institutes of Health/National Cancer Institute [2P50CA093459, P30CA023108]
- Marit Peterson Fund for Melanoma Research
- National Health and Medical Research Council of Australia (NHMRC) [566946, 107359, 211172, 402761, 200071, 241944, 339462, 380385, 389927, 389875, 389891, 389892, 389938, 443036, 442915, 442981, 496610, 496675, 496739, 552485, 552498]
- Cancer Council New South Wales [77/00, 06/10]
- Cancer Council Victoria
- Cancer Council Queensland [371]
- US National Institutes of Health (via NIH RO1) [CA-83115-01A2]
- Victorian Cancer Agency Early Career Seed Grant [ECSG07_010]
- Cancer Institute NSW [10/ECF/2-06]
- NHMRC [496610, 520018, 339446, 619667]
- Australian National Health and Medical Research Council
- Australian Research Council
- Cancer Australia [1011143]
- Scott Kirkbride Melanoma Research Centre
- Melanoma Research Alliance
- NIH NCI [CA83115, CA88363, CA122838, CA87969, CA055075, CA100264, CA133996, CA49449]
- Cancer Council New South Wales
- Cancer Council Queensland
- Cancer Institute New South Wales
- Cooperative Research Centre for Discovery of Genes for Common Human Diseases (CRC)
- Cerylid Biosciences (Melbourne)
- Australian Cancer Research Foundation
- National Health and Medical Research Council (NHMRC) of Australia [496610]
- National Cancer Institute [5 RO1 CA 001833-02]
- United States National Cancer Institute [CA 001833-03]
- National Health and Medical Research Council of Australia
- MRC [MR/L01629X/1] Funding Source: UKRI
- Cancer Research UK [16565, 10589, 16561, 19167] Funding Source: researchfish
- Medical Research Council [MR/L01629X/1] Funding Source: researchfish
- The Francis Crick Institute
- Cancer Research UK [10124] Funding Source: researchfish
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
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