期刊
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
卷 107, 期 1, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/dju360
关键词
-
类别
资金
- National Cancer Institute at the National Institutes of Health [UM1 CA167552, T32CA009001, R25CA098566, R01CA141298, R01CA133891, R25CA112355]
- Department of Defense [W81XWH-09-1-0243]
- Prostate Cancer Foundation
- NATIONAL CANCER INSTITUTE [R01CA133891, R25CA112355, UM1CA167552, R25CA098566, T32CA009001, R01CA141298] Funding Source: NIH RePORTER
Few studies have evaluated the relation between selenium supplementation after diagnosis and prostate cancer outcomes. We prospectively followed 4459 men initially diagnosed with nonmetastatic prostate cancer in the Health Professionals Follow-Up Study from 1988 through 2010 and examined whether selenium supplement use (from selenium-specific supplements and multivitamins) after diagnosis was associated with risk of biochemical recurrence, prostate cancer mortality, and, secondarily, cardiovascular disease mortality and overall mortality, using Cox proportional hazards models. All P values were from two-sided tests. We documented 965 deaths, 226 (23.4%) because of prostate cancer and 267 (27.7%) because of cardiovascular disease, during a median follow-up of 8.9 years. In the biochemical recurrence analysis, we documented 762 recurrences during a median follow-up of 7.8 years. Crude rates per 1000 person-years for prostate cancer death were 5.6 among selenium nonusers and 10.5 among men who consumed 140 or more mu g/day. Crude rates per 1000 person-years were 28.2 vs 23.5 for all-cause mortality and 28.4 vs 29.3 for biochemical recurrence, for nonuse vs highest-dose categories, respectively. In multivariable analyses, men who consumed 1 to 24 mu g/day, 25 to 139 mu g/day, and 140 or more mu g/day of supplemental selenium had a 1.18 (95% confidence interval [CI] = 0.73 to 1.91), 1.33 (95% CI = 0.77 to 2.30), and 2.60-fold (95% CI = 1.44 to 4.70) greater risk of prostate cancer mortality compared with nonusers, respectively, P (trend) = .001. There was no statistically significant association between selenium supplement use and biochemical recurrence, cardiovascular disease mortality, or overall mortality. Selenium supplementation of 140 or more mu g/day after diagnosis of nonmetastatic prostate cancer may increase risk of prostate cancer mortality. Caution is warranted regarding usage of such supplements among men with prostate cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据