期刊
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
卷 105, 期 24, 页码 1907-1911出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/djt300
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资金
- National Cancer Institute [R03CA159414, R01CA159036]
- Pancreatic Cancer Action Network-AACR Career Development Award
- Daniel and Janet Mordecai Foundation [12-20-25-AHN]
- Intramural Research Program of the National Institutes of Health/National Cancer Institute, Division of Cancer Epidemiology and Genetics
We tested the hypothesis that an altered community of gut microbes is associated with risk of colorectal cancer (CRC) in a study of 47 CRC case subjects and 94 control subjects. 16S rRNA genes in fecal bacterial DNA were amplified by universal primers, sequenced by 454 FLX technology, and aligned for taxonomic classification to microbial genomes using the QIIME pipeline. Taxonomic differences were confirmed with quantitative polymerase chain reaction and adjusted for false discovery rate. All statistical tests were two-sided. From 794 217 16S rRNA gene sequences, we found that CRC case subjects had decreased overall microbial community diversity (P=.02). In taxonomy-based analyses, lower relative abundance of Clostridia (68.6% vs 77.8%) and increased carriage of Fusobacterium (multivariable odds ratio [OR] = 4.11; 95% confidence interval [CI] = 1.62 to 10.47) and Porphyromonas (OR = 5.17; 95% CI = 1.75 to 15.25) were found in case subjects compared with control subjects. Because of the potentially modifiable nature of the gut bacteria, our findings may have implications for CRC prevention.
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