期刊
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
卷 100, 期 18, 页码 1326-1330出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/djn268
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资金
- National Institutes of Health (NIH) [U01CA76293]
- Genetic Epidemiology of Lung Cancer Consortium [R01CA058554, R01CA093643, R01CA099147, R01CA099187, R01ES012063, R01 ES013340, R03CA77118, R01CA80127, P30ES 06096, P50CA70907]
- Specialized Program of Re search Excellence [N01HG65404, N01-PC35145, P30CA22453, R01CA63700, DE-FGB-95ER62060, R01CA55769, R01CA121197, R01CA133996]
- Mayo Clinic intramural research funds
- Department of Defense VITAL grant
- National Cancer Institute
- National Human Genome Research Institute
Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
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