期刊
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
卷 100, 期 17, 页码 1204-1214出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/djn267
关键词
-
类别
资金
- MRC [MC_U122861330, MC_U122861386] Funding Source: UKRI
- Cancer Research UK [3804] Funding Source: Medline
- Medical Research Council [MC_U122861386, MC_U122861330] Funding Source: Medline
- Cancer Research UK [3804] Funding Source: researchfish
- Medical Research Council [MC_U122861330, MC_U122861386] Funding Source: researchfish
Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据