期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 88, 期 -, 页码 422-430出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2018.08.037
关键词
Shape memory polymers; Polyurethane; Glass transition temperature; Thermo-mechanical properties; Endovascular embolization
资金
- Oklahoma Center for the Advancement of Science and Technology (OCAST), USA [HR18-002]
- Oklahoma Shared Clinical and Translational Resources (OSCTR), USA [NIGMS U54GM104938]
- School of Aerospace and Mechanical Engineering (AME)
- SEED Funding for Interdisciplinary Research from the Gallogly College of Engineering
- Faculty Investment Program from the Research Council at the University of Oklahoma (OU)
- Mentored Research Fellowship from the Office of Undergraduate Research at OU
Intracranial aneurysms (ICAs) are focal dilations in the brain's arteries. When left untreated, ICAs can grow to the point of rupture, accounting for 50-80% of subarachnoid hemorrhage cases. Current treatments include surgical clipping and endovascular coil embolization to block circulation into the aneurysmal space for preventing aneurysm rupture. As for endovascular embolization, patients could experience aneurysm recurrence due to an incomplete coil filling or compaction over time. The use of shape memory polymers (SMPs) in place of conventional platinum coils could provide more control and predictability for mitigating these complications. This study was focused on characterization of an aliphatic urethane-based SMP to evaluate its potential as a novel biomaterial for endovascular embolization. Twelve compositions of the SMP were synthesized and their thermomechanical properties together with the shape recovery behavior were comprehensively investigated. Our results showed that the SMPs experienced a significant decrease in storage and loss moduli as heated above their glass transition temperatures (32.3-83.2 degrees C), and that all SMPs were thermally stable up to 265 degrees C. Moreover, the SMPs exhibited both composition-dependent stress relaxation and a decrease in elastic modulus during cyclic loading. The shape recovery time was less than 11 s for all SMP compositions, which is sufficiently short for shape changing during embolization procedures. Several candidate compositions were identified, which possess a glass transition temperature above body temperature (37 degrees C) and below the threshold of causing tissue damage (45 degrees C). They also exhibit high material strength and low stress relaxation behavior, suggesting their potential applicability to endovascular embolization of ICAs.
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