期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 32, 期 -, 页码 89-98出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2013.12.022
关键词
beta-TCP; PLA; Scaffolds; High pressure consolidation; Salt leaching; Permeability; Load bearing
资金
- GIF [1092-28.2/2010]
- German-Israeli Foundation for Scientific Research and Development
A modified particulate leaching method for fabrication of strong calcium phosphate-polymer composite scaffolds with improved pore interconnectivity is reported. The scaffolds were produced by mixing precomp acted composite granules (beta-TCP with 40 vol % PLA) of different size and density with salt particles followed by high pressure consolidation (at room temperature or 120 degrees C) and porogen dissolution. The scaffolds' compressive strength and Darcy's permeability were found to be inversely related and to be strongly dependent on the processing parameters. The use of precompacted granules instead of the loose beta-TCP-PLA powder allowed us to increase permeability by three orders of magnitude while maintaining load bearing characteristics. Scaffolds with 50% porosity prepared from large (300-420 mu m) composite granules of beta-TCP-40 vol% PLA and salt porogen particles of comparable size exhibited the best combination of compressive strength (4-6 MPa) and permeability (1.3-1.6 x 10(-10) m(2)) falling within the range of trabecular bone. (c) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据