期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 28, 期 -, 页码 26-36出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2013.07.016
关键词
Collagen scaffold; Multi-compartment; Mineral interface; Biophysical properties
资金
- UIUC from National Science Foundation (NSF) [0965918]
- Chemistry-Biology Interface Training Program NIH NIGMS [T32GM070421]
- Chemical and Biomolecular Engineering Department
- Institute for Genomic Biology (BAH) at the University of Illinois at Urbana-Champaign
- U.S. Department of Energy [DE-FG02-07ER46453, DE-FG02-07ER46471]
Orthopedic interfaces such as the tendon-bone junction (TBJ) present unique challenges for biomaterials development. Here we describe a multi-compartment collagen-GAG scaffold fabricated via lyophilization that contains discrete mineralized (CGCaP) and non-mineralized (CG) regions joined by a continuous interface. Modifying CGCaP preparation approaches, we demonstrated scaffold variants of increasing mineral content (40 vs. 80 wt% CaP). We report the impact of fabrication parameters on microstructure, composition, elastic modulus, and permeability of the entire multi-compartment scaffold as well as discrete mineralized and non-mineralized compartments. Notably, individual mineralized and non-mineralized compartments differentially impacted the global properties of the multi-compartment composite. Of particular interest for the development of mechanically-loaded multi-compartment composites, the elastic modulus and permeability of the entire construct were governed primarily by the non-mineralized and mineralized compartments, respectively. Based on these results we hypothesize spatial variations in scaffold structural, compositional, and mechanical properties may be an important design parameter in orthopedic interface repair. (C) 2013 Elsevier Ltd. All rights reserved.
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