期刊
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
卷 57, 期 5, 页码 573-579出版社
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
DOI: 10.1007/s13765-014-4157-2
关键词
anti-osteoporosis; antioxidant; cupric ion reducing antioxidant capacity; Euphorbia maculata; oxygen radical absorbance capacity; tartrate-resistant acid phosphatase
资金
- Priority Research Center Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology, Republic of Korea [2009-0093815]
- National Research Foundation of Korea [21A20132112763] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Antioxidant and anti-osteoporosis activities of extracts and chemical constituents from the whole plant of Euphorbia maculata were investigated. The MeOH extract, as well as EtOAc and H2O fractions (10.0 mu g/mL), exhibited potent antioxidant activities. Their oxygen radical absorbance capacity and cupric ion reducing antioxidant capacity values were 27.07 +/- 0.31 to 28.47 +/- 0.36 and 43.86 +/- 0.26 to 46.67 +/- 0.34 fold higher than those of 1.0 mu M Trolox, respectively. The MeOH extract and EtOAc fraction (at 10.0 mu g/mL) also significantly suppressed excessive bone resorption by osteoclasts with tartrate-resistant acid phosphatase (TRAP) activity values of 154.90 +/- 4.25 and 163.95 +/- 9.77%, respectively. Bioassay guided isolation of the EtOAc and H2O fractions afforded 19 known compounds (1-19). Of these, compounds 18, and 13-15 showed good antioxidant activity based on peroxyl radical-scavenging and reducing capacity assays, whereas compounds 1, 4, 7, and 14 showed the most significant inhibitory effect with TRAP activity values ranging from 121.31 +/- 1.41 to 110.00 +/- 3.74% relative to the control.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据