期刊
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
卷 55, 期 1, 页码 47-51出版社
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
DOI: 10.1007/s13765-012-0008-1
关键词
gamma-aminobutyric acid; alpha-amylase; ferulic acid alpha-glucosidase; Triticum aestivum sprouts
资金
- Korea Institute of Planning and Evaluation for Technology of Food, Agriculture, Forestry, and Fisheries, through Chonbuk National University [108156-03-1-SB010]
Inhibitory activities of the methanol extract from Triticum aestivum L. sprouts were examined against alpha-amylase and alpha-glucosidase. The active constituents of T. aestivum were isolated by chromatographic techniques and identified as gamma-aminobutyric acid and ferulic acid on the basis of IR and NMR. gamma-Aminobutyric acid and ferulic acid showed the high inhibitory activities with 1050 values of 5.4+/-0.2 and 9.5+/-0.1 mM against alpha-amylase, and 1.4 +/- 0.4 and 4.9 +/- 0.3 mM against alpha-glucosidase. The methoxy group on the hydroxycinnamic acid of ferulic acid derivatives played important functions in the alpha-amylase and alpha-glucosidase inhibitory activities. Based on the IC50 values of nitrite-scavenging activity, ferulic acid (98+/-3.9 mu g/mL) was the most effective constituent, followed by gamma-aminobutyric acid (182 4.2 mu g/mL), sinapic acid (301+/-2.7 mu g/mL), and p-coumaric acid (454+/-2.2 mu g/mL). These results indicate that gamma-aminobutyric acid and ferulic acid could be useful as preventative agents, and possibly therapeutic modalities for the treatment of metabolic diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据