期刊
POLYMERS FOR ADVANCED TECHNOLOGIES
卷 26, 期 5, 页码 449-456出版社
WILEY
DOI: 10.1002/pat.3472
关键词
photo-responsive micelles; self-assembly; o-nitrobenzyl ester; polyesters
资金
- Fundamental Research Funds for Central Universities
Photo-responsive block copolymer mPEG-b-poly(Tyr)-g-NB was prepared by introduction of o-nitrobenzyl ester group into the side chain of amphiphilic poly(ethylene glycol)-b-poly(-hydroxy acids) (mPEG-b-poly(Tyr)) containing pendent alkynyl group via copper-catalyzed azide-alkyne cycloaddition reaction. The amphiphilic mPEG-b-poly(Tyr) was synthesized via the ring-opening polymerization of O-carboxyanhydrides, with monomethoxy poly(ethylene glycol) (mPEG) as macroinitiator. The molecular structure, self-assembly, and photo-controlled release of the obtained mPEG-b-poly(Tyr)-g-NB were thoroughly investigated. mPEG-b-poly(Tyr)-g-NB could self-assemble into spherical micelles in water and showed disassembly under UV light irradiation, which was demonstrated by means of UV-vis spectroscopy, scan electron microscopes, and dynamic light scattering measurement. Fluorescence emission measurements demonstrated that Nile red, encapsulated by micelles, can be released upon UV irradiation. This study provides a convenient way to construct smart poly(-hydroxy acids)-based nanocarriers for controlled release of hydrophobic drugs. Copyright (c) 2015 John Wiley & Sons, Ltd.
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