期刊
POLYMERS FOR ADVANCED TECHNOLOGIES
卷 26, 期 12, 页码 1370-1377出版社
WILEY
DOI: 10.1002/pat.3636
关键词
endothelial cells; gene carrier; proliferation; targeting; endothelialization
资金
- National Natural Science Foundation of China [31370969]
- International Cooperation from Ministry of Science and Technology of China [2013DFG5204]
- Ph.D. Programs Foundation of Ministry of Education of China [20120032110073]
Artificial vascular scaffolds have been developed and used clinically for many years, but the lack of a living functional layer of human umbilical vein endothelial cells (HUVECs) remains a significant challenge, especially for small diameter artificial blood vessels. Endothelialization of artificial vascular scaffolds has been proved as one of the most potential approaches to improve their hemocompatibility and long-term patency. A variety of non-viral gene carriers have been investigated to mediate the transfection and proliferation of HUVECs. In this mini-review, we will summarize the recent development of the non-viral gene carriers for transfecting HUVECs. The gene transfection with targeting ligand immobilized carriers is a promising approach to enhance endothelialization of artificial vascular scaffolds. Copyright (C) 2015 John Wiley & Sons, Ltd.
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