期刊
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
卷 55, 期 4, 页码 432-446出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03602559.2015.1098684
关键词
-tricalcium phosphate; hot-melt extrusion; regenerative medicine
Biodegradable polymerspolyethylene oxide and poly (E-caprolactone)were melt extruded with -tricalcium phosphate. Breakdown analysis revealed that the percentage increase in bioceramic caused a prolonged degradation rate, with samples containing 20wt% -tricalcium phosphate losing significantly less weight over time in comparison to the control sample. Compression testing of samples following submission in aqueous environments revealed the composites exhibited enhanced strength with increasing bioceramic loading. The mechanical properties were significantly reduced over a period of 5 weeks. It was found that hot-melt extrusion of -tricalcium phosphate is a viable and effective method of producing novel composite scaffolds with potential for regenerative medicine applications.
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