Uncatalyzed and solvent-free one-pot three component synthesis of α-amino phosphonates

An innovative route to preaper a number of variously substituted alpha-aminophosphonate is presented. The protocol avoids the use Of any catalyst, organic solvents, and dry reaction conditions. The synthesis of alpha-aminophosphonates in the present study represents a three-component reaction in which no intermediate formation of either an imine or a-hydroxy phosphonate was observed.