期刊
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
卷 18, 期 3, 页码 541-555出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617712000069
关键词
Neuropsychology; Cognition; Executive function; Inhibition; Alzheimer disease; Dementia; Mild cognitive impairment; Working memory; Verbal fluency; Planning; Brown-Peterson task; Letter-Number Sequencing; Hayling test; Tower of London; Stroop test
资金
- Axe Cognition of the Reseau Quebecois de Recherche sur le Viellissement
- Fonds de la Recherche en Sante du Quebec
- Center for Research in Human Development, Concordia University
- Canadian Institutes of Health Research
- Pfizer Canada
- Lundbeck Canada
- Bristol Myers Squib
Amnestic mild cognitive impairment (aMCI) represents a group of individuals who are highly likely to develop Alzheimer's disease (AD). Although aMCI is typically conceptualized as involving predominantly deficits in episodic memory, recent studies have demonstrated that deficits in executive functioning may also be present, and thorough categorization of cognitive functioning in MCI may improve early diagnosis and treatment of AD. We first provide an extensive review of neuropsychology studies that examined executive functioning in MCI. We then present data on executive functioning across multiple sub-domains (divided attention, working memory, inhibitory control, verbal fluency, and planning) in 40 aMCI patients (single or multiple domain) and 32 normal elderly controls (NECs). MCI patients performed significantly worse than NECs in all 5 sub-domains, and there was impairment (> 1.0 SD below the mean of NECs) in all sub-domains. Impairment on each test was frequent, with 100% of MCI patients exhibiting a deficit in at least one sub-domain of executive functioning. Inhibitory control was the most frequently and severely impaired. These results indicate that executive dysfunction in multiple sub-domains is common in WO and highlights the importance of a comprehensive neuropsychological evaluation for fully characterizing the nature and extent of cognitive deficits in MCI. (JINS, 2012, 18, 541-555)
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