期刊
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
卷 15, 期 3, 页码 476-481出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617709090584
关键词
Adolescents; Bipolar disorder; Magnetic resonance imaging; Prefrontal cortex; Development; Longitudinal
资金
- National Institute of Mental Health [R01MH69747, R01MH070902, T32MH14276]
- National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke [R01NS35193]
- Department of Veterans Affairs Research Enhancement Award Program
- National Alliance for Research in Schizophrenia and Depression
- Attias Family Foundation
- Marcia Simon Kaplan
- Ethel F. Donaghue Women's Investigator Program at Yale
- Klingenstein Foundation
- NIH/National Institute of Biomedical Imaging and Bioengineering [R01EB006494]
- National Center for Research Resources (NCRR) [UL1 RR024139]
Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive Volume abnormalities during adolescence in bipolar disorder (1313). In the present study, a within-subject, longitudinal design was implemented to examine brain Volume changes during adolescence/young adulthood. We hypothesized that VPFC volume decreases over time would be greater in adolescents/young adults with BD than in healthy comparison adolescents/young adults. Eighteen adolescents/young adults (10 with BID I and 8 healthy comparison participants) underwent two high-resolution magnetic resonance imaging scans over approximately 2 years. Regional volume changes over time were measured. Adolescents/young adults with BD displayed significantly greater Volume loss over time, compared to healthy comparison participants, in a region encompassing VPFC and rostral PFC and extending to rostra] anterior cingulate cortex (p<.05). Additional areas where volume change differed between groups were observed. While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD. (JINS, 2009, 15, 476-481.)
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