期刊
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
卷 113, 期 3, 页码 143-147出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.jfma.2013.11.006
关键词
coronavirus; drug design; Middle East; vaccines
资金
- National Natural Science Foundation of China [81373311, 31300674, 81173093, 30970643, J1103518]
- Special Program for Youth Science and Technology Innovative Research Group of Sichuan Province, China [2011JTD0026]
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another SARS-like threat to the world. It has an extremely high death rate (similar to 50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs. Copyright (C) 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
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