期刊
POLYMER CHEMISTRY
卷 6, 期 4, 页码 531-542出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4py01380h
关键词
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资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2013R1A2A2A04015914]
In this study, a series of amphiphilic AB2-type 3-miktoarm copolymers consisting of hydrophilic poly(ethylene glycol) (PEG) as the A arm and hydrophobic poly(e-caprolactone) (PCL) as the two B arms were synthesized through the ring-opening polymerization of e-caprolactone (CL) using a PEG macroinitiator with a bi-arm structure. The self-assembly behavior, drug-loading capacities, and controlled drug release features of the PEG-PCL2 miktoarm copolymers were compared with those of their linear diblock counterparts (PEG-PCL). The PEG-PCL2 miktoarm copolymer with a relatively short PCL arm length (PEG volume fraction, f(PEG) = 0.55) self-assembled in aqueous solution to form a spherical micelle structure. However, cylindrical micelles were observed for the miktoarm copolymers with long PCL arms (fPEG = 0.15-0.32), whereas the corresponding linear counterparts consistently formed spherical micelle structures regardless of the PCL arm lengths. Drug-loading using doxorubicin (DOX) as the model drug indicated that the PEG-PCL2 cylindrical micelles possessed superior drug-loading capacities compared with the spherical micelles of the corresponding diblock copolymers. Furthermore, although the DOX-loaded cylindrical micelles exhibited a slower release rate than the DOX-loaded spherical micelles, the former exhibited higher cellular uptake and improved cytotoxic effects than the latter. These findings demonstrate the useful morphological versatility of the miktoarm-structured PEG-PCL block copolymers in comparison with the conventionally used linear diblock copolymers in the design of self-assembled nanocarriers for efficient drug delivery.
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