期刊
POLYMER CHEMISTRY
卷 6, 期 31, 页码 5565-5574出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5py00750j
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资金
- National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) [P20GM103541]
- NIGMS from the NIH [1 P30 GM110758-01]
- Burroughs Wellcome Fund
- University of Delaware Research Foundation
- University of California, Davis
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P30GM110758, P20GM103541] Funding Source: NIH RePORTER
Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing micro-environments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.
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