期刊
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
卷 29, 期 6, 页码 1193-1197出版社
WILEY-BLACKWELL
DOI: 10.1111/jdv.12789
关键词
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类别
资金
- department of dermatology of Radboud university medical center in Nijmegen
- Netherlands from Merck-Serono
- Wyeth
- Abbott
- Pfizer
- Janssen
- MSD
- Abbvie
- Astellas
- Leo Pharma
BackgroundEvidence on efficacy and safety of topical treatments for paediatric scalp psoriasis is lacking. ObjectiveThis study aims to evaluate the effectiveness and safety of calcipotriene/betamethasone dipropionate scalp formulation for paediatric scalp psoriasis in daily clinical practice. The influence of this formulation on the quality of life (QoL) was assessed as well. MethodsData of children treated with the scalp formulation were extracted from a prospective observational daily clinical practice registry of children with psoriasis, called Child-Continuous Assessment of Psoriasis Treatment Use Registry. Severity was expressed by Psoriasis Scalp Severity Index (PSSI) and the impact on the QoL was reflected by the validated Children's Scalpdex in Psoriasis (CSP). ResultsEighty-four treatment episodes were analysed. Significant improvements of PSSI score (18.711.8 to 12.7 +/- 9.4) were demonstrated in the first 12weeks and this result was well maintained during 48weeks of follow-up. Three patients (4.1%) developed striae of the skin (arms, trunk and legs), which are possibly related to the scalp formulation. CSP scores (79.0-46.3) declined significantly after 3months. ConclusionIn a daily clinical practice cohort of children with scalp psoriasis, calcipotriene/betamethasone dipropionate scalp formulation was effective with a 32.1% improvement of PSSI at week 12 and a maintenance of this effect until 48weeks of follow-up, in combination with improvement of QoL.
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