期刊
POLYMER CHEMISTRY
卷 6, 期 13, 页码 2401-2406出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5py00047e
关键词
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资金
- Chinese National Nature Science Foundation [21405115, 21374081, 51433005]
- National Thousand Talents Program, Zhejiang Nature Science Foundation [LQ14C100002]
- Zhejiang Department of Education [Y201223055]
- Wenzhou Bureau of Science and Technology [Y20120218]
- NSF [CMMI-1266295]
A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.
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