期刊
POLYMER CHEMISTRY
卷 6, 期 5, 页码 772-779出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4py00931b
关键词
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资金
- National Natural Science Foundation of China [21174071, 21474055]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130031110014]
- Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education of China [IRT1257]
- Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)
- Tianjin Natural Science Foundation [14JCYBJC29400]
With the increasing concern over drug-resistant bacterial infections, in particular hospital-acquired infections, there is an urgent need to develop effective and safe antibacterial agents. Herein, a study aiming at developing a good antibacterial agent with high antibacterial activity and low cytotoxicity to promote public health is reported. Composite copolymer hybrid silver nanoparticles (AgNPs) were synthesized via the reduction of NaBH4 in the presence of copolymers and AgNO3. The composite copolymers containing 2-(dimethylamino) ethyl methacrylate (DMAEMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) segments were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization, and then the copolymers were quaternized to increase AgNPs adhesion to bacterial membranes through electrostatic interactions. The copolymer hybrid AgNPs showed high antibacterial activity against P. aeruginosa (Gram-negative bacteria) and S. aureus (Gram-positive bacteria), which could inhibit bacterial proliferation even if the concentration was 8 mu g mL(-1). Furthermore, copolymer hybrid AgNPs had negligible haemolysis and low cytotoxicity. The nanoparticles destroyed the bacterial membrane irreversibly and then caused the release of cytoplasmic constituents and cell death finally. These results suggest that copolymer hybrid AgNPs have potential use as antibacterial agents in clinical applications.
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