NiFe-Layered Double Hydroxide Sheets as an Efficient Electrochemical Biosensing Platform

The maximum allowed limits of chlorpromazine (CPZ) established by Food and Drug Administration (FDA) for children aged between 1 and 5 years is 0.125 mM and between 6 to 12 years is 0.235 mM. However, excess consumption of CPZ beyond these permissible limit cause adverse health effects. In order to detect CPZ, herein, we employ NiFe-layered double hydroxide sheets modified glassy carbon electrode (GC/NiFe LDH). The GC/NiFe LDH electrode exhibited a good electrocatalytic activity towards CPZ detection at a less working potential even in the presence of interferents such as ascorbic acid, uric acid, glucose, sucrose, fructose and acetaminophen. The anodic peak observed at 614 mV (vs. Ag/AgCl) corresponds to the oxidation of CPZ and the proposed platform exhibited an excellent linearity in the range 75 mu M to 1.0 mM. Further, the GC/NiFe LDH electrode exhibited an excellent sensitivity (1.05 mu A mu M-1), repeatability (0.86% RSD), reproducibility (1.54% RSD) and limit of detection (1.23 mu M). (C) 2018 The Electrochemical Society.