期刊
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
卷 73, 期 5, 页码 225-229出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/S1726-4901(10)70048-4
关键词
acyl ghrelin; diabetes mellitus; feeding; gastrointestinal motility; ghrelin O-acyltransferase
资金
- Taipei Veterans General Hospital, Taiwan [V95C1-096, V96C1-112]
- Sapporo Medical University for the Promotion of Medical Science, Japan
Acyl ghrelin, a 28-amino acid peptide hormone, is the endogenous cognate ligand for the growth hormone secretagogue receptor. Ghrelin is involved in stimulating growth hormone release, eliciting feeding behavior, inducing adiposity and stimulating gastrointestinal motility. Ghrelin is unique for its post-translational modification of O-n-octanoylation at serine 3 through ghrelin O-acyltransferase, and is the only peripheral signal to enhance food intake. Plasma ghrelin levels manifest biphasic changes in diabetes mellitus (DM). In the early stage of DM, the stomach significantly increases the secretion of ghrelin into the plasma, and elevated plasma ghrelin levels are correlated with diabetic hyperphagic feeding and accelerated gastrointestinal motility. In the late stage of DM, plasma ghrelin levels may be lower, which might be linked with anorexia/muscle wasting, delayed gastrointestinal transit, and even gastroparesis. Therefore, the unique ghrelin system may be the most important player compared to the other hindgut hormones participating in the enteroinsular axis. Further studies using either knockdown or knockout of ghrelin gene products and ghrelin O-acyltransferase may unravel the pathogenesis of DM, and show benefits in combating this disease and metabolic syndrome. [J Chin Med Assoc 2010:73(5):225-229]
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