期刊
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
卷 58, 期 1, 页码 24-30出版社
CHINESE CHEMICAL SOC
DOI: 10.1002/jccs.201190053
关键词
3 '-Azido-2 '-deoxythymidine (AZT); 1,2,3-Triazole; 1,3-Dipolar cycloaddition
资金
- Natural Science Foundation of China [20472076, 21072178]
- Innovation Specialist Projects of Henan Province
An efficient synthesis of novel mono and bis-1,2,3-triazoles 3'-azido-2'-deoxythymidine (AZT) derivatives via copper(I)-catalyzed 1,3-dipolar cycloaddition reaction is described. Starting from AZT and terminal alkyne derivatives, mono and bis-1,2,3-triazole AZT derivatives are regioselectively obtained in good yields under mild conditions using CuSO(4)center dot 5H(2)O and sodium ascorbate as a catalyst system, and t-BuOH/H(2)O (1:1, v/v) as a co-solvent. The structures of these compounds were elucidated by IR, HR MS and NMR.
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