期刊
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
卷 56, 期 1, 页码 127-134出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jccs.200900018
关键词
Peptide; Molecular recognition; Imprinting; Macrocycles; Synthesis design
资金
- Taiwan National Science Council [NSC 92-2113-M-259-005, NSC 93-2113-M-259-009]
Based on the fabrication of molecularly imprinted polymeric film on cellulose paper (MIFC), we have developed a robotic system for homodetic tetrapeptide cyclization. We constructed molecularly imprinted polymeric film (MIPF) on cellulose paper as the non-covalent auxiliary to assist cyclic tetrapeptide (CTP) formation. Tetrapeptides were bound by their hydrophobic interaction with MIFC. With the help of MIFC and a coupling reagent, quantitative synthesis of CTPs was achieved conveniently for various tetrapeptides. The syntheses of cyclic tetrapeptide (CTP) could also be facilitated using the MIFC induced from CTP or other tetrapeptides with partially matched sequences.
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