期刊
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
卷 55, 期 2, 页码 356-361出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jccs.200800052
关键词
diclofenac; ion associates; determination; spectrophotometry
资金
- Ministry of Education and Science of Ukraine and International Visegrad Fund [997015]
- Scientific Grant Agency of the Ministry of Education of the Slovak Republic
- Slovak Academy of Sciences [1/4450/07]
- Slovak Research and Development Agency [APVV SK-UA-0002-07]
A new simple, rapid and sensitive spectrophotometric method has been developed for the determination of diclofenac sodium (Dicl) in pharmaceutical preparations. This method is based on the reaction of diclofenac sodium with an analytical reagent 1,3,3-trimethyl-5-thiocyanato-2-[3-(1',3',3'-trimethyl-3'H-indol-2'-ylidene)-propenyl]-indolium cloride (TIC) at pH 8.0-11.0 and the extraction of ion associate colored complex. Optimal conditions for the complex formation between Dicl and TIC were studied. This ion associate complex (1: 1) was detected and extracted with toluene and an absorption maximum at 566.2 nm against a blank reagent. The calibration graph was linear from 0.9-11.0 mu g/mL of diclofenac and the detection limit was 0.86 mu g/mL.
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