期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 30, 期 2, 页码 406-412出版社
SOC BRASILEIRA QUIMICA
DOI: 10.21577/0103-5053.20180190
关键词
Lobophora variegata; brown algae; 3,4-epoxy lobophorenes; antiproliferative activity
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (CAPES/FUNCAP) [88887.113263/201501]
- Instituto Nacional de Ciencia e Tecnologia (INCT BioNat) [465637/2014-0]
Two new polyunsaturated 3,4-epoxy-heneicosane derivatives named as epoxy-lobophorene A and epoxy-lobophorene B were isolated from the brown alga Lobophora variegata, in addition to nine known compounds. The structures of the new compounds were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The isolated compounds were submitted to antiproliferative assays against the human colon cancer cell line HCT-116, human metastatic prostate cancer PC-3M, murine metastatic melanoma B16-F10 and murine fibroblast cell line L929 and also tested as antibacterial. Both 3,4-epoxy lobophorene A and 3,4-epoxy lobophorene B depicted moderate antiproliferative effect against cell lines. None of them showed antibacterial activity.
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